What Would Genrich Do?

Here's a contradiction Mr. Altschuler :

You want your pixel to be as sensitive as possible - when it gets electrons, you want it to generate as big of a voltage as possible so you overpower the noise of the readout circuitry as much as possible.

Problem : the more signal voltage you get per electron, the faster you're using up the available range that that node provides the voltage due to headroom limitations. So, you're losing dynamic range.

What's a brother to do? No wonder TI has no use for Joyce anymore.