What Do They Do Inside You : Ozempic, Wegovy, and Mounjaro for Weight Loss

Aka, what's driven Eli Lilly and Novo Nordisk stock to such massive gains in the last year? 😊

FYI, WSJ spoke to Dr. D. Narang of Northwestern.

Fun fact, once a drug has FDA approval, doctors can prescribe it for off-label use. So, these (GLP-1 class drugs) might be intended for diabetes, but doctors can prescribe them for weight loss.

They work on both the gut and the brain.

At the level of the gut, the medication slows down gastric emptying, so it slows down the way your stomach empties into your gut. It takes longer for food to get from your stomach to the rest of your digestive tract. That leads to feeling fuller faster than usual.

At the level of the brain, it interacts with your appetite center and suppresses your hunger hormone.

GLP-1 (Glucagon-Like Peptide-1) is a hormone produced in the intestine that plays an important role in regulating blood sugar levels. It is released in response to food intake, particularly when carbohydrates and fats are consumed. GLP-1 acts on various organs in the body, including the pancreas, stomach, and brain.

GIP (Glucose-Dependent Insulinotropic Polypeptide), also known as gastric inhibitory polypeptide, is a hormone produced by the intestines. Similar to GLP-1, GIP plays a role in regulating blood sugar levels and insulin secretion.

When we eat, GIP is released in response to the presence of nutrients, particularly carbohydrates and fats. Its main function is to stimulate the release of insulin from the pancreas. Insulin helps to lower blood sugar levels by allowing glucose to enter cells for energy or storage.

GIP is often referred to as an incretin hormone, along with GLP-1, because both hormones are released after a meal and enhance the secretion of insulin. They work in conjunction to help regulate blood sugar levels.

Wall Street Journal : Buy WMT!!

Apparently their e-commerce is doing well..

Looking at their chart, I'd say it makes sense - they seem to be the classic cup and handle.

Now that's what I Call Great Journalism

Except, what's President Dumb going to do about it? He's going to ban immigration into the top paying charities, that's what.

https://www.gfmag.com/topics/syndicate/39743130-charity-officials-are-increasingly-receiving-million-dollar-paydays

Anthony Tersigni : Ascension Health Alliance : $18 million, about 30b in operating revenue

Congratulations Andrea Fuller.

"The leaders of one small ministry earned several times that. Hal Lindsey and his wife, JoLynn, operate Hal Lindsey Website Ministries, a Texas-based evangelical group. Mr. Lindsey hosts the "Hal Lindsey Report, " available online and on Christian television networks, and is the author of books on current events and prophecy.

The charity's revenue in 2014, which came almost solely from contributions, was $8.1 million. The ministry paid Mr. Lindsey $2.2 million and his wife $1.8 million. For each, this included a $1.5 million bonus.

Mr. Lindsey, 87 years old, and his wife, 62, declined to be interviewed. In a written statement, Mr. Lindsey said the bonuses were approved by the board and intended as one-time retirement benefits. He said he worked many years for little or no compensation.

The ministry's IRS filings show it paid Mr. Lindsey less than $50,000 during most years in the early 2000s but paid him and his wife a total of more than $7.8 million from 2007 through 2014."

What about Paula Wallace!! Head of Savannah College of Art and Design - how do they rake in $400 million  year? She raked in $10 million in 2014 and at least 1m a year for the prior 10 years. Here's what she's bragging about :

Letter from the president

Welcome!

Thirty-eight years ago, my family and I invented SCAD ex nihilo. I still marvel at the faith that the very first SCAD students and professors placed — sight unseen — in what would soon become a revolution in higher education. In founding SCAD, I was led by the principle that education is a fundamentally optimistic endeavor, one that presupposes that minds and bodies can be transformed through changes in behavior. Further, I believed that this same principle applied to arts education. Creativity can be taught and refined!