FYI, WSJ spoke to Dr. D. Narang of Northwestern.
Fun fact, once a drug has FDA approval, doctors can prescribe it for off-label use. So, these (GLP-1 class drugs) might be intended for diabetes, but doctors can prescribe them for weight loss.
They work on both the gut and the brain.
At the level of the gut, the medication slows down gastric emptying, so it slows down the way your stomach empties into your gut. It takes longer for food to get from your stomach to the rest of your digestive tract. That leads to feeling fuller faster than usual.
At the level of the brain, it interacts with your appetite center and suppresses your hunger hormone.
GLP-1 (Glucagon-Like Peptide-1) is a hormone produced in the intestine that plays an important role in regulating blood sugar levels. It is released in response to food intake, particularly when carbohydrates and fats are consumed. GLP-1 acts on various organs in the body, including the pancreas, stomach, and brain.
GIP (Glucose-Dependent Insulinotropic Polypeptide), also known as gastric inhibitory polypeptide, is a hormone produced by the intestines. Similar to GLP-1, GIP plays a role in regulating blood sugar levels and insulin secretion.
When we eat, GIP is released in response to the presence of nutrients, particularly carbohydrates and fats. Its main function is to stimulate the release of insulin from the pancreas. Insulin helps to lower blood sugar levels by allowing glucose to enter cells for energy or storage.
GIP is often referred to as an incretin hormone, along with GLP-1, because both hormones are released after a meal and enhance the secretion of insulin. They work in conjunction to help regulate blood sugar levels.
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